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Probing the modulation in facilitated diffusion guided by DNA-protein interactions in target search processes.

Diljith Thonnekottu1, Debarati Chatterjee2,1

  • 1Department of Physics, Indian Institute of Technology Palakkad, Kerala 678623, India.

Physical Chemistry Chemical Physics : PCCP
|June 26, 2024
PubMed
Summary

Facilitated diffusion, a mix of 1D sliding and 3D movement, speeds up how proteins find DNA sequences. This study quantizes search dynamics, revealing DNA flexibility and target location impact protein search efficiency.

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