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White Matter Abnormalities Track Disease Progression in Multiple System Atrophy.

Sheelakumari Raghavan1, Timothy G Lesnick2, Anna M Castillo2

  • 1Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Movement Disorders Clinical Practice
|June 26, 2024
PubMed
Summary
This summary is machine-generated.

White matter abnormalities are central to multiple system atrophy (MSA) progression, affecting both subtypes similarly. Longitudinal MRI can track these brain changes in clinical trials.

Keywords:
DTIMRImultiple system atrophy

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Area of Science:

  • Neuroimaging
  • Neurology
  • Neurodegeneration

Background:

  • White matter (WM) abnormalities are linked to functional decline in multiple system atrophy (MSA).
  • Understanding these changes is crucial for tracking disease progression.

Purpose of the Study:

  • Identify white matter (WM) and gray matter (GM) abnormalities in MSA.
  • Assess longitudinal structural and diffusion MRI changes as surrogate markers for disease progression.

Main Methods:

  • Prospective, longitudinal study of 27 early MSA patients (MSA-C and MSA-P) and 14 controls.
  • Utilized structural and diffusion MRI (DT-MRI, NODDI) to analyze brain changes.
  • Evaluated temporal imaging trajectories with up to three annual follow-up scans.

Main Results:

  • MSA patients showed more widespread WM than GM changes, especially in the cerebellum and brainstem.
  • Cerebellum WM and brainstem structural and diffusion measures worsened with disease progression.
  • Progression rates were similar across MSA subtypes, indicating clinical feature overlap.

Conclusions:

  • WM abnormalities are key features of MSA progression, advancing at similar rates in subtypes.
  • Multimodal MRI provides insights into MSA brain abnormalities and their progression.
  • Selected MRI measures show potential for tracking MSA progression in clinical trials.