Related Experiment Video
Updated: Jun 23, 2025
09:14
Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
Published on: June 13, 2014
16.1K
Rab GTPases, Active Members in Antigen-Presenting Cells, and T Lymphocytes
Nidia Carolina Moreno-Corona1, Mercedes Piedad de León-Bautista2,3, Moises León-Juárez4
1Laboratory of Human Lymphohematopoiesis, Imagine Institute, INSERM UMR 1163, Université de Paris, Paris, France.
Traffic (Copenhagen, Denmark)
|June 26, 2024
Summary
Rab GTPases are crucial for vesicular trafficking in immune cells. This review focuses on their specific roles in dendritic cells and T/B lymphocytes, expanding beyond macrophage research.
Area of Science:
- Cell Biology
- Immunology
- Molecular Biology
Background:
- Vesicular trafficking, including cell migration, phagocytosis, endocytosis, and exocytosis, is vital for cellular communication.
- Rab GTPases and associated proteins (SNAREs, coat proteins, cytoskeleton) regulate vesicle transport in eukaryotic cells.
Purpose of the Study:
- To review the specific functions of Rab GTPases in immune cells.
- To elucidate the mechanisms of Rab GTPase contribution in dendritic cells (DCs) and T/B lymphocytes.
Main Methods:
- Literature review focusing on Rab GTPase functions in immune cell vesicular trafficking.
- Analysis of molecular mechanisms involving Rab GTPases, adaptor proteins, and cytoskeletal elements.
Main Results:
- Rab GTPases are essential regulators of vesicular trafficking in immune cells.
- This review highlights the distinct roles of Rab GTPases in DCs and lymphocytes, complementing existing macrophage-focused studies.
Conclusions:
- Understanding Rab GTPase functions in DCs and lymphocytes is critical for immune cell biology.
- Further research into these specific mechanisms can reveal new therapeutic targets in immunology.
Related Concept Videos
01:24Small GTPases - Ras and Rho
3.9K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
Three regulatory proteins control their activity:
3.9K
01:22Activation and Inactivation of G Proteins
7.0K
Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
7.0K
02:14GTPases and their Regulation
8.3K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒ small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
Large G-proteins,...
8.3K
01:14Rab Proteins
3.9K
Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
3.9K
01:25Rab Cascades
2.6K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
2.6K
01:22Antigen Presenting Cells
1.7K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
1.7K