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Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
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Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

714

Potential Impact of Bioactive Peptides from Foods in the Treatment of Hypertension

Natalia Ichim1, Francisco Marín2, Esteban Orenes-Piñero1,3

  • 1Department of Biochemistry and Molecular Biology-A, University of Murcia, Murcia, 30071, Spain.

Molecular Nutrition & Food Research
|June 26, 2024
PubMed

Insights

Food-derived bioactive peptides show potential for managing high blood pressure (BP). These natural compounds, particularly those with specific molecular characteristics, offer a promising alternative for hypertension treatment and prevention.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Nutrition Science

Background:

  • High blood pressure (BP) is a primary preventable risk factor for cardiovascular diseases (CVDs).
  • Hypertension (HT) management faces challenges due to patient non-responsiveness to pharmacological treatments and adverse side effects.
  • Research is exploring natural alternatives for hypertension control and prevention.

Purpose of the Study:

  • To review the role of food-derived bioactive peptides in managing hypertension (HT).
  • To identify characteristics of effective antihypertensive peptides.
  • To assess the potential of these peptides in functional foods, nutraceuticals, and pharmaceuticals.

Main Methods:

  • A comprehensive literature search was conducted across various scientific databases.
  • Forty relevant articles were selected for analysis.
  • Mechanisms of action, peptide characteristics, and study methodologies were evaluated.

Main Results:

  • Angiotensin-converting enzyme (ACE) inhibition is the predominant mechanism of action for antihypertensive peptides.
  • Optimal antihypertensive activity is associated with biopeptides <3 kDa, <20 amino acids, and specific hydrophobic sequences.
  • These peptides demonstrate good stability, low toxicity, and are evaluated through in vitro, in vivo, and limited in silico/human studies.

Conclusions:

  • Food-derived bioactive peptides represent a promising natural avenue for hypertension management.
  • These peptides hold significant potential for development into functional foods, nutraceuticals, and therapeutic drugs.
  • Further research, including clinical trials, is warranted to fully realize their therapeutic benefits.
Abstract

Keywords:
ACE inhibitorantihypertensive treatmentbioactive peptidescryptide

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