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Comparison of the penile microbiome in infant male circumcision: Mogen clamp versus Shangring

Juan E Salazar1, Daniel E Park1, Nahid Punjani2

  • 1Antibiotic Resistance Action Center, Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, 20052, USA.

Ebiomedicine
|June 26, 2024
PubMed
Abstract

Insights

Early infant male circumcision (EIMC) using Mogen Clamp or ShangRing alters the penile microbiome. Both methods reduce anaerobes and uropathogens, similar to adult circumcision outcomes.

Area of Science:

  • Microbiology
  • Urology
  • Pediatrics

Background:

  • The infant penile microbiome composition and its alteration by early infant male circumcision (EIMC) are not well-characterized.
  • EIMC is performed using various methods, including surgical (Mogen Clamp) and non-surgical (ShangRing) devices.

Purpose of the Study:

  • To characterize the infant penile (coronal sulcus) microbiome.
  • To assess the effects of two EIMC methods (Mogen Clamp and ShangRing) on the infant penile microbiome.

Main Methods:

  • A randomized trial was conducted in Uganda involving 30 infants undergoing EIMC.
  • Coronal sulcus swabs were collected at baseline and on days 7 and 14 post-circumcision.
  • 16S rRNA gene sequencing and qPCR were used to analyze the penile microbiome composition.

Main Results:

  • Prior to EIMC, the infant penile microbiome comprised a mix of facultative and strict anaerobes.
  • EIMC, by both Mogen Clamp and ShangRing, led to a decrease in anaerobic bacteria (e.g., Prevotella, Veillonella).
  • EIMC resulted in an increase in skin-associated facultative anaerobes (e.g., Corynebacterium, Staphylococcus).

Conclusions:

  • Both Mogen Clamp and ShangRing EIMC significantly alter the infant penile microbiome composition.
  • These changes involve a reduction in anaerobes and uropathogens, consistent with findings in adult male circumcision studies.
  • Neither EIMC method led to an increase in Clostridium tetani detection.
Keywords:
AnaerobeEarly infant male circumcision (EIMC)Infant coronal sulcus microbioimeInfant penile microbiomeMogen clampShangringTetanusUropathogen

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