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Relationship between atherosclerotic burden and depressive symptoms in hypertensive patients: A cross-sectional study

Ting Chen1, Yuan Qian2, Xingli Deng3

  • 1Department of Neurosurgery, Kunming Medical University First Affiliated Hospital, Kunming, Yunnan 650032, China.

Journal of Affective Disorders
|June 26, 2024
PubMed

Insights

Atherosclerotic burden, measured by Atherosclerotic Index of Plasma (AIP), is linked to more severe depressive symptoms and a higher risk of clinically relevant depression (CRD) in hypertensive patients.

Area of Science:

  • Cardiovascular Medicine
  • Psychiatry
  • Public Health

Background:

  • Hypertension is a significant global health concern.
  • The interplay between cardiovascular health and mental well-being, specifically depression, requires further investigation.
  • Atherosclerotic burden is a key factor in cardiovascular disease progression.

Purpose of the Study:

  • To investigate the association between atherosclerotic burden, quantified by Atherosclerotic Index of Plasma (AIP), and depressive symptoms in hypertensive patients.
  • To explore the relationship between AIP and the risk of clinically relevant depression (CRD) among individuals with hypertension.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (NHANES) database, focusing on patients diagnosed with hypertension.
  • Employed weighted logistic regression and weighted linear regression models to analyze the associations between AIP, depressive symptoms, and CRD risk.
  • Applied restrictive cubic spline curves to assess potential nonlinear relationships and conducted subgroup analyses to ensure robustness.

Main Results:

  • A significant positive association was found between AIP and the severity of depressive symptoms in hypertensive patients.
  • High AIP levels were significantly correlated with an increased risk of clinically relevant depression (CRD) in this population.
  • These associations remained consistent across various demographic and clinical subgroups.

Conclusions:

  • Atherosclerotic Index of Plasma (AIP) is identified as a significant risk factor for clinically relevant depression (CRD) in patients with hypertension.
  • Increased atherosclerotic burden in hypertensive individuals is demonstrably linked to the severity of their depressive symptoms.
  • These findings highlight the importance of considering cardiovascular health in the management of depression among hypertensive patients.
Abstract

Keywords:
Atherosclerotic index of plasma (AIP)Clinically relevant depressionDepressionHypertensionNHANES

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