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Functional Constipation: Pathophysiology, evaluation, and management.

Alexandra Kilgore1, Julie Khlevner2

  • 1Digestive Health Institute, Children's Hospital Colorado, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Alimentary Pharmacology & Therapeutics
|June 26, 2024
PubMed
Summary
This summary is machine-generated.

Pediatric functional constipation (FC) management is evolving. Treatment now integrates parental education, lifestyle changes, and expanded pharmacological options like linaclotide, alongside traditional therapies for improved outcomes.

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Area of Science:

  • Gastroenterology
  • Pediatrics
  • Gut-Brain Interaction

Background:

  • Functional constipation (FC) is a common pediatric gut-brain interaction disorder.
  • It causes significant distress, impacts quality of life, and increases healthcare burdens.
  • Risk factors include stressful life events and behavioral challenges.

Purpose of the Study:

  • To review current concepts in the pathophysiology of pediatric FC.
  • To outline updated evaluation and management strategies for pediatric FC.
  • To highlight recent advancements in diagnosing and treating this condition.

Main Methods:

  • Comprehensive literature search using PubMed.
  • Keywords included: FC, chronic childhood constipation, and pediatric FC.
  • Review focused on recent advancements in the last decade.

Main Results:

  • Understanding of pediatric FC pathophysiology has advanced significantly.
  • Polyethylene glycol remains a first-line maintenance therapy.
  • New treatments, including FDA-approved linaclotide for ages 6-17, are now available, alongside behavioral and physical therapies.

Conclusions:

  • Individualized, integrated treatment is key for pediatric FC.
  • Management should combine parental education, lifestyle/behavioral modifications, and pharmacotherapy.
  • Recent advances offer improved therapeutic success for children with FC.