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Unveiling the axonal connectivity between the precuneus and temporal pole: Structural evidence from the cingulum
Georgios P Skandalakis1,2, Wen-Jieh Linn3, Fang-Cheng Yeh3
1Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Human Brain Mapping
|June 26, 2024
Summary
Researchers mapped structural connections between the precuneus and temporal pole (TP) using fiber micro-dissections and tractography. A direct pathway, the fifth cingulum subcomponent (CB-V), was identified, enhancing understanding of brain networks.
Area of Science:
- Neuroscience
- Neuroanatomy
- Brain Connectivity
Background:
- Neuroimaging shows concurrent precuneus and temporal pole (TP) activation during rest and cognitive tasks.
- Precise structural connectivity between these regions remains unclear despite neuroimaging advances.
Purpose of the Study:
- To investigate the structural connectivity between the human precuneus and temporal pole (TP).
- To elucidate the specific pathways linking these brain regions.
Main Methods:
- Utilized parcellation-based fiber micro-dissections in human brains.
- Employed fiber tractography on 1065 human subjects and 41 rhesus macaques.
Main Results:
- Identified connectivity between the posterior precuneus (POS2) and TP areas (35, 36, TG) via the fifth cingulum subcomponent (CB-V), also known as the parahippocampal cingulum.
- CB-V pathway demonstrated associations with cingulum, SRF, forceps major, and ILF.
- Human and macaque tractography results consistently supported micro-dissection findings.
Conclusions:
- Established a direct axonal connection between the posterior precuneus and specific temporal pole regions.
- This finding advances the understanding of posteromedial cortex connections and brain function integration.
- Provides anatomical basis for integrating function and structure in normal and pathological brain states.
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