The Prognostic Significance of Transient Receptor Potential Canonical 1 and Its Association with Vascular Endothelial Growth Factor Receptor 2 in Papillary Thyroid Carcinoma Patients
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View abstract on PubMed
Summary
This summary is machine-generated.Transient receptor potential canonical 1 (TRPC1) is linked to increased invasion and relapse risk in papillary thyroid carcinoma (PTC). Higher TRPC1 levels correlate with poorer disease-free survival and elevated vascular endothelial growth factor receptor 2 (VEGFR2) in PTC patients.
Area Of Science
- Oncology
- Molecular Biology
- Pathology
Background
- Transient receptor potential canonical 1 (TRPC1) is implicated in cancer cell proliferation and metastasis.
- The role of TRPC1 in papillary thyroid carcinoma (PTC) and its association with vascular endothelial growth factor receptor 2 (VEGFR2) remain unclear.
Purpose Of The Study
- To investigate the prognostic significance of TRPC1 expression in PTC.
- To examine the correlation between TRPC1 and VEGFR2 in PTC patients.
Main Methods
- Retrospective analysis of TRPC1 and VEGFR2 immunohistochemistry (IHC) scores in 287 PTC patients and 30 thyroid benign lesion (TBL) patients.
- Correlation of TRPC1 IHC scores with clinicopathological features and patient survival (DFS, OS).
- Time-dependent area under the curve (AUC) analysis for relapse and death risk prediction.
Main Results
- TRPC1 expression was significantly higher in PTC tissues compared to TBL tissues (P = 0.006).
- Elevated TRPC1 scores correlated with extrathyroidal invasion (P = 0.028) and pathological node stage 1 (P = 0.011).
- TRPC1 IHC score > 3 was associated with shortened disease-free survival (DFS) (P = 0.005) and overall survival (OS) (P = 0.020), and independently predicted shorter DFS (HR = 2.948, P = 0.045).
- TRPC1 expression showed a positive association with VEGFR2 expression in PTC (P = 0.010).
Conclusions
- TRPC1 expression is associated with tumor invasion and lymph node metastasis in PTC.
- High TRPC1 expression (>3) serves as an independent predictor of shorter DFS in PTC patients.
- TRPC1 is linked to increased VEGFR2 expression and elevated disease relapse risk in PTC.
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