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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: Jun 17, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

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Close margin of adverse histologic factors with a negative primary tumor margin is not associated with increased

Moustafa Moussally1, Maysoon M GamalEldin1, James E Lapinski2

  • 1Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.

American Journal of Surgery
|June 26, 2024
PubMed
Summary
This summary is machine-generated.

Close margins of specific colon cancer histologic factors, like intravascular or intranodal tumor, do not appear to increase locoregional recurrence risk. This finding suggests these factors may not necessitate additional adjuvant therapy in colon cancer patients.

Keywords:
Colon cancerHistologic factorsLocoregional recurrenceMargins

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Area of Science:

  • Oncology
  • Surgical Pathology
  • Gastrointestinal Cancer Research

Background:

  • Positive primary tumor margins in colon cancer resection correlate with increased locoregional recurrence.
  • Limited data exists on the locoregional recurrence risk associated with close margins (<1 mm) of specific adverse histologic factors.

Purpose of the Study:

  • To investigate the association between close margins (<1 mm) of adverse histologic factors and locoregional recurrence in colon cancer.
  • To test the hypothesis that close margins of intravascular tumor, intranodal tumor, tumor deposits, or extranodal extension do not elevate locoregional recurrence risk.

Main Methods:

  • Retrospective review of colon cancer (adenocarcinoma) surgical resections from 2007-2020.
  • Inclusion criteria: negative primary tumor margin with close (<1 mm) adverse histologic factors (intravascular, intranodal, tumor deposits, extranodal extension) near mesenteric or circumferential margins.
  • Analysis of recurrence patterns in included cases.

Main Results:

  • 45 cases (1%) met inclusion criteria from 4435 pathology reports.
  • Intranodal tumor was the most frequent factor (53%), followed by intravascular tumor (17.8%).
  • 9% of patients experienced recurrence, with only 2 (4%) having locoregional recurrence only. The adverse factors in these cases were intravascular or both intravascular and intranodal.

Conclusions:

  • The study found no evidence linking close margins of intravascular tumor, intranodal tumor, tumor deposits, or extranodal extension to an increased risk of locoregional recurrence in colon cancer.
  • These specific close margin histologic factors may not independently predict locoregional recurrence after resection.