Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

  1. Home
  3. Close Margin Of Adverse Histologic Factors With A Negative Primary Tumor Margin Is Not Associated With Increased Locoregional Recurrence In Colon Cancer.
  1. Home
  3. Close Margin Of Adverse Histologic Factors With A Negative Primary Tumor Margin Is Not Associated With Increased Locoregional Recurrence In Colon Cancer.

Related Experiment Video

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

248

Close margin of adverse histologic factors with a negative primary tumor margin is not associated with increased

Moustafa Moussally1, Maysoon M GamalEldin1, James E Lapinski2

  • 1Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.

American Journal of Surgery
|June 26, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
Colon cancerHistologic factorsLocoregional recurrenceMargins

More Related Videos

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

3.7K
Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

454

Related Experiment Videos

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

248
Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

3.7K
Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

454

Close margins of specific colon cancer histologic factors, like intravascular or intranodal tumor, do not appear to increase locoregional recurrence risk. This finding suggests these factors may not necessitate additional adjuvant therapy in colon cancer patients.

Area of Science:

  • Oncology
  • Surgical Pathology
  • Gastrointestinal Cancer Research

Background:

  • Positive primary tumor margins in colon cancer resection correlate with increased locoregional recurrence.
  • Limited data exists on the locoregional recurrence risk associated with close margins (<1 mm) of specific adverse histologic factors.

Purpose of the Study:

  • To investigate the association between close margins (<1 mm) of adverse histologic factors and locoregional recurrence in colon cancer.
  • To test the hypothesis that close margins of intravascular tumor, intranodal tumor, tumor deposits, or extranodal extension do not elevate locoregional recurrence risk.

Main Methods:

  • Retrospective review of colon cancer (adenocarcinoma) surgical resections from 2007-2020.
  • Inclusion criteria: negative primary tumor margin with close (<1 mm) adverse histologic factors (intravascular, intranodal, tumor deposits, extranodal extension) near mesenteric or circumferential margins.
  • Analysis of recurrence patterns in included cases.

    • Main Results:

    • 45 cases (1%) met inclusion criteria from 4435 pathology reports.
    • Intranodal tumor was the most frequent factor (53%), followed by intravascular tumor (17.8%).
    • 9% of patients experienced recurrence, with only 2 (4%) having locoregional recurrence only. The adverse factors in these cases were intravascular or both intravascular and intranodal.

    Conclusions:

    • The study found no evidence linking close margins of intravascular tumor, intranodal tumor, tumor deposits, or extranodal extension to an increased risk of locoregional recurrence in colon cancer.
    • These specific close margin histologic factors may not independently predict locoregional recurrence after resection.