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Pulse rhythm01:30

Pulse rhythm

Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac muscle...

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Related Experiment Video

Updated: Jun 21, 2026

Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes
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Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes

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Tracking single hiPSC-derived cardiomyocyte contractile function using CONTRAX an efficient pipeline for traction

Gaspard Pardon1,2,3,4,5, Alison S Vander Roest1,3,6,7, Orlando Chirikian8

  • 1Departments of Mechanical Engineering and of Bioengineering, Stanford University, School of Engineering and School of Medicine, Stanford, CA, USA.

Nature Communications
|June 26, 2024
PubMed
Summary

CONTRAX is a new open-access pipeline for tracking human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) contractility. This tool enables high-throughput analysis of cellular function over time, aiding in cardiomyopathy and cardiotoxicity research.

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Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Cardiovascular Research

Background:

  • Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are crucial in vitro models for studying heart diseases and drug toxicity.
  • High-throughput, time-resolved quantification of hiPSC-CM contractile function is vital for understanding cellular mechanisms impacting heart function.

Purpose of the Study:

  • To introduce CONTRAX, an open-access, versatile pipeline for quantitative tracking of single hiPSC-CM contractile dynamics over time.
  • To provide a streamlined approach for analyzing large numbers of hiPSC-CMs under various experimental conditions.

Main Methods:

  • CONTRAX comprises three software modules for cell identification, automated video acquisition (>200 cells/hour), and contractility measurement using traction force microscopy.
  • Analysis of over 4,500 hiPSC-CMs across different culture media, substrate stiffnesses, drug treatments, and in the presence of cardiac mutations.

Main Results:

  • Undirected clustering revealed consistent hiPSC-CM maturation patterns.
  • Quantifiable drug responses to Mavacamten were observed.
  • Significant functional deficiencies were identified in hiPSC-CMs carrying disease mutations.

Conclusions:

  • CONTRAX offers a powerful quantitative method for analyzing hiPSC-CM contractility.
  • This pipeline can accelerate the development of novel cardiac therapies by providing detailed insights into cellular function and disease mechanisms.