Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease
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View abstract on PubMed
Summary
This summary is machine-generated.Lipid and bile acid profiles differ significantly between sexes in patients with coronary artery disease (CAD). These sex-specific differences in lipidomics may help explain varying CAD progression in men and women.
Area Of Science
- Cardiovascular Medicine
- Metabolomics
- Lipidomics
Background
- Lipids, including phospholipids and bile acids, play roles in signaling and coronary artery disease (CAD) development.
- Understanding sex-specific lipid profiles in CAD is crucial for personalized medicine.
Purpose Of The Study
- To compare lipidomic and bile acid profiles in blood of patients with and without CAD, stratified by sex.
- To investigate potential sex-specific contributions of lipids and bile acids to CAD pathogenesis.
Main Methods
- Analysis of 177 matched patients from the INTERCATH cohort (2015-2022) undergoing coronary angiography.
- Lipidomic analysis using the Lipidyzer platform and bile acid analysis via LC-MS/MS.
- Matching algorithm based on age, BMI, cardiovascular risk factors, and medication use.
Main Results
- Women with CAD showed decreased phosphatidylcholine and diacylglycerol levels; no bile acid differences were found compared to women without CAD.
- Men with CAD exhibited decreased secondary bile acids (glycolithocholic, lithocholic acid) and altered lipid profiles compared to men without CAD.
- In men with CAD and low LDL-c, increased phospholipid species, particularly plasmalogens, were observed compared to those with high LDL-c.
Conclusions
- Hypothesis-generating data reveal sex-specific lipidomic patterns and bile acid profiles in CAD patients.
- Altered lipid and bile acid profiles may contribute to CAD development and progression.
- Findings aid in understanding divergent CAD disease trajectories between sexes.
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