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Updated: Jun 22, 2025
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Vascular Ehlers-Danlos syndrome and pregnancy: A systematic review
Théo Haem1, Betty Benson2, Amandine Dernoncourt3,4
1Department of Gynaecology and Obstetrics, Centre Hospitalier Universitaire Amiens Picardie, Amiens, France.
Background:
Vascular Ehlers-Danlos syndrome (vEDS) is a hereditary connective tissue disorder associated with an elevated risk of vascular, uterine and digestive complications. Managing pregnancy in this context can be a challenge.
Objectives:
To systematically review the literature data on the complications in pregnancy associated with vEDS.
Search Strategy:
We searched the Pubmed Medline and Embase databases for articles using the following terms "vascular Ehlers-Danlos syndrome" or "vEDS" AND "pregnancy".
Selection Criteria:
Women with vEDS.
Data Collection And Analysis:
We searched the PubMed® MEDLINE® database for publications evaluating obstetric outcomes in women with vEDS.
Main Results:
A total of 121 publications were screened, with six (accounting for 412 pregnancies) included in our review. Of the women included in this sample, 30% were infertile. The miscarriage rate was 13.8% (57/412) and 8.8% of the live births were premature. Obstetric anal sphincter injuries occurred in 11.3% (23/203) of the deliveries. The maternal mortality rate per pregnancy was 5.7%.
Conclusions:
Women with vEDS present an elevated risk of uterine rupture, vascular events, digestive events and death during pregnancy. Women appear to be most at risk during the peripartum period; to avoid expulsive efforts, a caesarean section should be scheduled at 37 weeks of gestation.
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