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Updated: Jun 22, 2025

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

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Published on: June 7, 2015

Recent Research Progress on Polyamidoamine-Engineered Hydrogels for Biomedical Applications.

Li Liu¹, Zhiling Li¹, Baiyan Yang¹

¹Outpatient Department of Anhui Medical University First Affiliated Hospital, The First Affiliated Hospital of Anhui Medical University, No. 120 Wanshui Road, Hefei High-Tech Zone, Hefei 230000, China.

|June 27, 2024

Summary

Polyamidoamine dendrimers enable the creation of advanced hydrogels for biomedical uses. These functional materials show promise in drug delivery, tissue engineering, and tumor therapy.

Keywords:

drug delivery hydrogel nanohydrogel polyamidoamine dendrimer tissue engineering

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Last Updated: Jun 22, 2025

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Published on: June 7, 2015

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The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

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Published on: October 7, 2016

Area of Science:

Materials Science
Biomedical Engineering
Polymer Chemistry

Background:

Hydrogels are 3D crosslinked materials mimicking the extracellular matrix, widely used in biomedical applications.
Polyamidoamine (PAMAM) dendrimers, with abundant peripheral amino groups, are key for engineering functional hydrogels.
PAMAM dendrimers offer versatile platforms for creating multifunctional hydrogels with tailored properties.

Purpose of the Study:

To review recent advancements in designing multifunctional hydrogels using PAMAM dendrimers.
To discuss synthesis strategies and diverse biomedical applications of PAMAM-based hydrogels.
To highlight the potential of PAMAM-engineered nano-hydrogels.

Main Methods:

Review of synthesis methods including click chemistry, aza-Michael addition, Schiff base reactions, amidation, enzymatic reactions, and radical polymerization.
Compilation of research on applications in drug delivery, tissue engineering, and drug-free tumor therapy.
Summarization of studies on PAMAM-engineered nano-hydrogels.

Main Results:

PAMAM dendrimers facilitate the synthesis of various functional hydrogels.
These hydrogels demonstrate significant potential in drug delivery, tissue engineering, and cancer therapy.
PAMAM-based nano-hydrogels integrate benefits of dendrimers, hydrogels, and nanoparticles.

Conclusions:

PAMAM dendrimers are crucial for developing advanced, multifunctional hydrogel materials.
The review provides insights for designing novel PAMAM-based hydrogels for biomedical applications.
Further research in this area can lead to innovative therapeutic and regenerative strategies.