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Lesions induced by trauma in pemphigoid
The British Journal of Dermatology
|October 1, 1979
Summary
Scratching can induce pemphigoid lesions, even during corticosteroid treatment. This phenomenon offers insights into early pemphigoid immunopathology and may link to epidermolysis bullosa acquisita.
Area of Science:
- Dermatology
- Immunopathology
- Autoimmune Blistering Diseases
Background:
- Pemphigoid is an autoimmune blistering disease.
- Trauma is not typically considered a primary cause of pemphigoid lesions.
Observation:
- Three patients with pemphigoid (adult and juvenile types) developed bullous lesions after scratching.
- In two patients, trauma-induced lesions appeared early in systemic corticosteroid therapy while other lesions were healing.
Findings:
- Scratching-induced bullous lesions were observed in pemphigoid patients.
- This phenomenon may be more prominent in epidermolysis bullosa acquisita, suggesting a pemphigoid variant.
Implications:
- Trauma-induced pemphigoid lesions can provide a model for studying early immunopathological events.
- Understanding trauma's role may refine pemphigoid diagnosis and management strategies.