Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Focused ultrasound for brain metastases.

Neuro-oncology advances·2026
Same author

Applications of transcranial focused ultrasound for primary brain tumors.

Neuro-oncology advances·2026
Same author

Polarization increases nuclear stiffness in macrophages despite reduction in lamin A/C levels.

npj biological physics and mechanics·2026
Same author

Neurocognitive Outcomes Following Venous Sinus Stenting versus Ventriculoperitoneal Shunting in Idiopathic Intracranial Hypertension.

AJNR. American journal of neuroradiology·2026
Same author

Endovascular thrombectomy versus medical management for large vessel occlusion stroke patients with brain malignancy.

AJNR. American journal of neuroradiology·2026
Same author

The TNFR superfamily member Fn14 impacts immunity and survival in experimental gliomas and response to immune checkpoint inhibitor therapy in glioblastoma patients.

Neuro-oncology advances·2026

Related Experiment Video

Updated: Jun 22, 2025

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
14:10

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

16.0K

Microbubble-Enhanced Focused Ultrasound for Infiltrating Gliomas.

Alexandra A Seas1, Adarsha P Malla1, Nima Sharifai2,3

  • 1Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Biomedicines
|June 27, 2024
PubMed
Summary

Microbubble-enhanced focused ultrasound (MB-FUS) shows promise for treating brain tumors by opening the blood-brain barrier. This technology may improve drug delivery, liquid biopsy, and immunotherapy for glioma patients.

Keywords:
acoustic emissionsblood-brain barrierfocused ultrasoundglioblastomahigh-grade gliomasimmunotherapyinfiltrating gliomasmicrobubbles

More Related Videos

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
08:02

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Published on: July 16, 2020

4.8K
Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability
06:29

Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability

Published on: February 5, 2022

4.3K

Related Experiment Videos

Last Updated: Jun 22, 2025

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
14:10

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

16.0K
A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
08:02

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Published on: July 16, 2020

4.8K
Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability
06:29

Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability

Published on: February 5, 2022

4.3K

Area of Science:

  • Neuro-oncology
  • Medical imaging
  • Ultrasound technology

Background:

  • Infiltrating gliomas are difficult to treat due to the blood-brain barrier (BBB).
  • Current treatments for high-grade gliomas have limited success and poor patient outcomes.
  • Microbubble-enhanced focused ultrasound (MB-FUS) is a novel technology for BBB opening.

Purpose of the Study:

  • To review recent advancements in focused ultrasound for glioma treatment.
  • To discuss the potential of MB-FUS in enhancing drug delivery, liquid biopsy, and immunotherapy.
  • To explore future applications of image-guided precision therapy using focused ultrasound.

Main Methods:

  • Review of preclinical and clinical studies on focused ultrasound for gliomas.
  • Analysis of MB-FUS applications in opening the blood-brain barrier.
  • Exploration of emerging research in MB-FUS for liquid biopsy and immunotherapy augmentation.

Main Results:

  • MB-FUS has demonstrated safety and efficacy in opening the BBB in various models, including gliomas.
  • The technology's potential extends beyond drug delivery to enhancing liquid biopsy and immunotherapy.
  • Recent studies show progress in preclinical and clinical applications of focused ultrasound for glioma treatment.

Conclusions:

  • MB-FUS is a promising technology for overcoming BBB limitations in glioma treatment.
  • Future applications may involve image-guided precision therapies for more effective glioma management.
  • Continued research in MB-FUS holds significant potential for improving patient outcomes in neuro-oncology.