Evaluation of PAGE-B Score for Hepatocellular Carcinoma Development in Chronic Hepatitis B Patients: Reliability,...

Area of Science:

• Hepatology
• Oncology
• Public Health

Background:

• Chronic hepatitis B (CHB) is a significant global health concern, contributing to liver disease and hepatocellular carcinoma (HCC).
• Effective management of CHB requires diligent monitoring for HCC development, especially in patients receiving antiviral therapy.
• Existing prognostic scores for HCC risk may have limitations in accuracy, particularly for treated CHB patients.

Purpose of the Study:

• To evaluate the efficacy of the PAGE-B score in predicting HCC development in CHB patients.
• To assess the PAGE-B model's accuracy, validity, and reliability compared to other risk scoring systems.
• To provide insights for optimizing HCC surveillance strategies in CHB patients.

Main Methods:

• Review of existing literature on HCC risk prediction in CHB patients.
• Analysis of the PAGE-B model's performance, considering age, gender, and platelet count.
• Comparison of PAGE-B with alternative prognostic scores for HCC surveillance.

Main Results:

• The PAGE-B model demonstrates high accuracy, validity, and reliability in predicting HCC occurrence in CHB patients on nucleos(t)ide analogue treatment.
• PAGE-B shows superior predictive performance compared to other risk scoring systems.
• Potential exists for further enhancing PAGE-B's predictive accuracy through targeted adjustments.

Conclusions:

• The PAGE-B score is a dependable tool for accurately predicting HCC development in CHB patients.
• PAGE-B can guide recommendations for HCC surveillance in this high-risk population.
• Continued evaluation and potential refinement of the PAGE-B score are warranted for improved patient management.