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Related Concept Videos

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  3. Research Domains
  5. Physical Sciences
  7. Condensed Matter Physics
  9. Surface Properties Of Condensed Matter
  11. Investigating The Free Volumes As Nanospaces In Human Stratum Corneum Lipid Bilayers Using Positron Annihilation Lifetime Spectroscopy (pals).
  1. Home
  3. Research Domains
  5. Physical Sciences
  7. Condensed Matter Physics
  9. Surface Properties Of Condensed Matter
  11. Investigating The Free Volumes As Nanospaces In Human Stratum Corneum Lipid Bilayers Using Positron Annihilation Lifetime Spectroscopy (pals).

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Investigating the Free Volumes as Nanospaces in Human Stratum Corneum Lipid Bilayers Using Positron Annihilation Lifetime Spectroscopy (PALS).

Krystyna Mojsiewicz-Pieńkowska1, Dagmara Bazar1, Jacek Filipecki2

  • 1Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. Józefa Hallera 107, 80-416 Gdańsk, Poland.

International Journal of Molecular Sciences
|June 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Positron annihilation lifetime spectroscopy (PALS) confirms free volumes in human skin, revealing their size and location within lipid bilayers, crucial for molecular diffusion.

Keywords:
PALS techniquefree volume in lipids bilayersfree volume in stratum corneummolecular properties of stratum corneum

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Area of Science:

  • Materials Science
  • Biophysics
  • Dermatology

Background:

  • The human stratum corneum's structure and transport properties are not fully understood.
  • Previous studies hypothesized the existence of free volumes but lacked direct experimental evidence.

Purpose of the Study:

  • To provide the first experimental evidence for free volumes in the human stratum corneum.
  • To compare experimental free volume data with theoretical values.
  • To investigate the role of these free volumes in molecular diffusion.

Main Methods:

  • Positron annihilation lifetime spectroscopy (PALS) was employed to probe free volumes.
  • The Tao-Eldrup model was used to analyze PALS data and estimate void characteristics.
  • Experimental data were compared with existing theoretical models.
nanospaces in stratum corneum
positron annihilation lifetime spectroscopy

Main Results:

  • Experimental evidence for the existence of free volumes in the human stratum corneum was established.
  • Key parameters such as free volume radius (0.269 nm), size (0.081 nm³), and fractional free volume (1.32 a.u.) were quantified.
  • A slight discrepancy was observed between experimental (0.269 nm) and theoretical (0.4 nm) mean free volume values.
  • The lifetime of o-Ps (τ₃) was found to correlate with the size of these open spaces.

Conclusions:

  • PALS is a powerful technique for detecting and characterizing free volumes in biological tissues.
  • Free volumes are likely located within the SC lipid bilayers, influencing molecular transport.
  • The molecular dynamics of lipid chains are responsible for the formation of these nanospaces, impacting diffusion.