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Updated: Jun 22, 2025

Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice
Published on: August 22, 2011
Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury
Wojciech Czyżewski1,2, Jakub Litak3, Jan Sobstyl4
1Department of Neurosurgery, Maria Sklodowska-Curie National Research Institute of Oncology, ul. W.K. Roentgena 5, 02-781 Warsaw, Poland.
Abstract:
Aquaporins (AQPs), particularly AQP4, play a crucial role in regulating fluid dynamics in the brain, impacting the development and resolution of edema following traumatic brain injury (TBI). This review examines the alterations in AQP expression and localization post-injury, exploring their effects on brain edema and overall injury outcomes. We discuss the underlying molecular mechanisms regulating AQP expression, highlighting potential therapeutic strategies to modulate AQP function. These insights provide a comprehensive understanding of AQPs in TBI and suggest novel approaches for improving clinical outcomes through targeted interventions.
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