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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Multipotency of Hematopoietic Stem Cells01:19

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Updated: Jun 22, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Leukemic Stem Cells and Hematological Malignancies.

Hee-Seon Choi1, Byoung Soo Kim2, Sik Yoon3

  • 1Department of Convergence Medicine, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.

International Journal of Molecular Sciences
|June 27, 2024
PubMed
Summary
This summary is machine-generated.

Leukemic stem cells (LSCs) drive blood cancer development and recurrence. Targeting these resilient cells and their resistance mechanisms offers a promising strategy to improve treatment outcomes for hematological malignancies.

Keywords:
hematological malignancyhematopoietic stem cellleukemialeukemic stem cell

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Area of Science:

  • Hematology
  • Cancer Biology
  • Stem Cell Biology

Background:

  • Leukemic stem cells (LSCs) are central to the development and progression of hematological malignancies.
  • Genetic and epigenetic alterations in hematopoietic stem cells (HSCs) and their microenvironment lead to dysregulation and blood cancer.
  • Standard therapies targeting blast cells often spare LSCs, contributing to disease recurrence and poor prognosis.

Purpose of the Study:

  • To comprehensively review the types of hematopoietic malignancies.
  • To elucidate the characteristics of leukemic stem cells (LSCs) driving these diseases.
  • To explore LSC chemoresistance mechanisms and targeted therapeutic strategies.

Main Methods:

  • Literature review of scientific articles on LSCs, hematological malignancies, and cancer therapy.
  • Analysis of genetic, epigenetic, and signaling pathway alterations in LSCs.
  • Synthesis of current research on LSC resistance mechanisms and novel therapeutic approaches.

Main Results:

  • LSCs possess unique self-renewal and differentiation capabilities that sustain leukemia.
  • Chemoresistance in LSCs is mediated by various mechanisms including altered drug metabolism and survival pathways.
  • Targeting LSC-specific pathways and vulnerabilities shows potential for overcoming treatment resistance.

Conclusions:

  • Understanding LSC biology is crucial for developing effective treatments for blood cancers.
  • Targeting LSCs and their resistance mechanisms represents a key strategy to improve patient survival and reduce relapse rates.
  • Further research into LSC-specific therapies is warranted to combat hematological malignancies.