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Updated: Jun 22, 2025

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
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The Role of the PAX Genes in Renal Cell Carcinoma

Lei Li1, Sultana Mehbuba Hossain1,2, Michael R Eccles1,2

  • 1Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.

International Journal of Molecular Sciences
|June 27, 2024
PubMed

Insights

The PAX gene family, particularly PAX2 and PAX8, plays a key role in renal cell carcinoma (RCC) development. Targeting PAX genes offers potential for novel RCC therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Renal cell carcinoma (RCC) presents a significant challenge due to its complexity and limited treatments.
  • The PAX gene family, crucial for development, is implicated in RCC occurrence and progression.
  • Clear cell RCC (ccRCC), the most common subtype, is linked to von Hippel-Lindau (VHL) gene loss.

Purpose of the Study:

  • To review the role of the PAX gene family in RCC tumorigenesis and progression.
  • To examine PAX gene expression and function in common RCC subtypes (ccRCC, PRCC, ChRCC).
  • To explore PAX gene interactions with VHL loss in RCC pathogenesis and potential therapeutic strategies.

Main Methods:

  • Literature review of published research on PAX genes in RCC.
  • Analysis of PAX gene expression patterns and functional implications.
  • Review of signaling pathways involving VHL and PAX in ccRCC pathogenesis.

Main Results:

  • PAX genes, especially PAX2 and PAX8, are implicated in the development and progression of RCC subtypes.
  • VHL loss in ccRCC may interact with PAX genes in disease pathogenesis.
  • PAX gene research provides insights into potential novel therapeutic targets for RCC.

Conclusions:

  • The PAX gene family is integral to RCC development and progression.
  • Understanding PAX-VHL interactions is crucial for elucidating ccRCC pathogenesis.
  • Targeting PAX genes represents a promising avenue for developing innovative RCC therapies.
Keywords:
PAX genesVHLclear cell renal cell carcinomarenal cell carcinomasubtypes

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