Higher EpCAM-Positive Extracellular Vesicle Concentration in Ascites Is Associated with Shorter Progression-Free Survival of Patients with Advanced High-Grade Serous Carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Higher levels of EpCAM-positive extracellular vesicles (EVs) in ascites indicate shorter progression-free survival in platinum-resistant high-grade serous carcinoma (HGSC) patients. These EVs may predict recurrence and chemoresistance in advanced ovarian cancer.
Area Of Science
- Oncology
- Biomarker Discovery
- Extracellular Vesicle Research
Background
- Platinum-resistant high-grade serous carcinoma (HGSC) presents a significant clinical challenge with limited treatment options.
- Tumor-derived extracellular vesicles (EVs) are emerging as promising biomarkers for monitoring disease progression and guiding treatment in HGSC.
- Epithelial cell adhesion molecule (EpCAM) expression is altered in epithelial cancers, but its prognostic role in ovarian cancer remains debated.
Purpose Of The Study
- To investigate the prognostic and predictive value of total and EpCAM-positive EVs in advanced HGSC.
- To assess the correlation of EpCAM-positive EVs between ascites and plasma as potential biomarkers.
Main Methods
- Flow cytometry was employed to quantify total and EpCAM-positive EVs.
- Paired ascites and plasma samples from 37 advanced HGSC patients were analyzed pre-treatment.
- Progression-free survival (PFS) was evaluated in relation to EV concentrations.
Main Results
- Elevated concentrations of EpCAM-positive EVs in ascites correlated with shorter PFS, irrespective of the first-line therapy received.
- A significant correlation was observed between EpCAM-positive EV levels in ascites and plasma.
- Higher EpCAM-positive EV levels suggest more aggressive tumor biology and potential chemoresistance.
Conclusions
- EpCAM-positive EVs in ascites show potential as prognostic biomarkers for predicting early recurrence in advanced HGSC.
- These EVs may aid in identifying patients with more aggressive disease and a higher likelihood of developing chemoresistance.
- The strong correlation between ascites and plasma EpCAM-positive EVs warrants further investigation for non-invasive biomarker development.
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