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Transcriptomic Profile of Mouse Brain Ageing in Early Developmental Stages.
Karolina Kulis1, Kevin Tabury2, Mohammed Abderrafi Benotmane2
1Department of Data Science and Engineering, Silesian University of Technology, 44-100 Gliwice, Poland.
Brain Sciences
|June 27, 2024
Summary
Early brain development reveals key ageing markers and pathways. This study identifies transcriptomic signatures of ageing in mouse brains, offering insights into neurodevelopment and age-related disorders.
Area of Science:
- Neuroscience
- Genomics
- Developmental Biology
Background:
- Ageing causes neurodevelopmental changes, but early brain development stages are understudied.
- Understanding early ageing is crucial for preventing neurological and psychiatric disorders.
Purpose of the Study:
- Identify transcriptomic markers of ageing in early brain development.
- Investigate time-dependent and tissue-independent gene expression changes.
Main Methods:
- Two-way ANOVA and effect size analysis on gene expression profiles in mouse brain regions.
- Analysis of time courses of gene expression in C57Bl/6J mice.
- Validation of markers using 11-day-old mouse embryo samples.
Main Results:
- 16,374 genes showed significant expression changes; 1823 were time-dependent and tissue-independent.
- 305 genes exhibited consistent time-response trends across brain regions.
- Functional analysis highlighted mitochondrial processing, contact activation system, and kallikrein/kinin system involvement.
Conclusions:
- Identified early-stage brain ageing biomarkers with potential for preventing age-related disorders.
- Ageing affects key pathways linked to development and neurodegeneration.
- Transcriptomic analysis provides a foundation for understanding early-life ageing processes.
