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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Related Experiment Video

Updated: Jun 20, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
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Published on: April 24, 2020

68Ga-PSMA PET/CT in Recurrent Prostate Cancer after Radical Prostatectomy Using PSMA-RADS Version 2.0.

Gabriele Masselli1,2, Saadi Sollaku2, Cristina De Angelis2

  • 1Department of Radiological Sciences, Oncology and Anatomo-Pathology, "Sapienza" University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.

Diagnostics (Basel, Switzerland)
|June 27, 2024
PubMed
Summary

Gallium-68 PSMA PET/CT imaging shows high detection rates for recurrent prostate cancer. The PSMA-RADS version 2.0 scoring system effectively classifies malignancy, correlating with PSA levels.

Keywords:
68Ga-PSMA68Ga-PSMA PET/CTPSMA-RADSbiochemical recurrenceprostate cancer

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Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiology

Background:

  • 68Ga-PSMA PET/CT is a superior imaging modality for detecting metastatic recurrent prostate cancer compared to standard methods.
  • Prostate-specific membrane antigen (PSMA) based imaging offers enhanced sensitivity in identifying disease recurrence.

Purpose of the Study:

  • To evaluate the diagnostic performance of 68Ga-PSMA PET/CT in a patient cohort.
  • To assess the utility of the PSMA-RADS version 2.0 classification system for recurrent prostate cancer detection.

Main Methods:

  • A retrospective analysis of 128 patients who underwent 68Ga-PSMA PET/CT for suspected recurrence post-prostatectomy.
  • Patients were assessed using the PSMA-RADS version 2.0 criteria, with categories 3-5 considered positive for malignancy.

Main Results:

  • The overall detection rate for recurrent prostate cancer was 71%.
  • Detection rates varied significantly with pre-examination PSA levels: 38% for PSA < 0.2 ng/mL, 57% for 0.2-0.5 ng/mL, 77% for 0.5-1 ng/mL, and 95% for PSA > 1 ng/mL.
  • PSMA-RADS v2.0 classification yielded results consistent with existing literature.

Conclusions:

  • 68Ga-PSMA PET/CT demonstrates high efficacy in detecting prostate cancer recurrence.
  • The PSMA-RADS version 2.0 provides a standardized approach for interpreting these scans.
  • Imaging performance is strongly correlated with baseline PSA levels, aiding in clinical decision-making.