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Related Experiment Video

Updated: May 12, 2026

Cecal Ligation Puncture Procedure

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

Presepsin in Critical Illness: Current Knowledge and Future Perspectives.

Paolo Formenti¹, Miriam Gotti¹, Francesca Palmieri¹

¹Department of Anesthesia and Intensive Care, ASST Nord Milano, Ospedale Bassini, 20097 Cinisello Balsamo, Italy.

Diagnostics (Basel, Switzerland)

|June 27, 2024

Summary

Presepsin (PSP) shows promise as a rapid, cost-effective biomarker for identifying infections in intensive care units (ICUs). This review explores its diagnostic accuracy and potential for improving sepsis management.

Keywords:

critical care patients presepsin sepsis

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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

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Last Updated: May 12, 2026

Cecal Ligation Puncture Procedure

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Area of Science:

Biochemistry
Immunology
Critical Care Medicine

Background:

Accurate infection identification in ICUs is crucial but challenged by current diagnostic limitations.
Existing methods lack sensitivity, specificity, cost-effectiveness, and rapid turnaround.
There is a need for a reliable, accessible, and economical biomarker for early infection detection.

Purpose of the Study:

To provide a comprehensive review of presepsin (PSP) as a biomarker in intensive care unit (ICU) settings.
To evaluate PSP's diagnostic accuracy, prognostic value, and therapeutic implications for infection and sepsis.
To discuss challenges and future research directions for PSP utilization in critical care.

Main Methods:

Literature review of studies on presepsin (PSP) in intensive care units (ICUs).
Analysis of diagnostic accuracy, including sensitivity and specificity, using various threshold values.
Evaluation of prognostic capabilities and impact on treatment decisions.

Main Results:

Presepsin (PSP), a marker of monocyte/macrophage activation, shows potential for early sepsis diagnosis.
PSP levels correlate with bacterial infection presence and decrease with effective antibiotic treatment.
Diagnostic accuracy of PSP for sepsis varies, necessitating further investigation into optimal thresholds and standalone utility.

Conclusions:

Presepsin (PSP) is a promising biomarker reflecting cellular immune response to bacterial infections.
Further research is needed to establish PSP's definitive role and optimal application in ICU infection management.
PSP offers potential advantages over traditional markers like procalcitonin (PCT) and C-reactive protein (CRP) due to its specific mechanism of action.