Oxidative Status, Iron Plasma Levels in Venous Thrombosis Patients

Area of Science:

• Biochemistry
• Hematology
• Pathophysiology

Background:

• Venous thromboembolism (VTE) is a significant health concern.
• Oxidative stress (OxS) is increasingly recognized as a potential risk factor for VTE.
• The interplay between iron (Fe) metabolism, hepcidin (Hep) regulation, and OxS in VTE pathogenesis requires further elucidation.

Purpose of the Study:

• To investigate the association between oxidative stress markers, plasma iron levels, and hepcidin protein levels in patients with venous thrombosis.
• To explore the potential role of iron dysregulation and oxidative stress in the development of VTE.

Main Methods:

• A case-control study was conducted with 20 hospitalized VTE patients and 20 healthy controls.
• Oxidative stress was assessed by measuring malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and superoxide dismutase (SOD).
• Plasma iron (Fe) and hepcidin (Hep) levels were quantified in both groups.

Main Results:

• VTE patients exhibited significantly higher levels of MDA and 4-HNE, and lower SOD activity compared to controls, indicating activated OxS.
• Plasma iron levels were elevated, and hepcidin levels were significantly higher in VTE patients than in healthy individuals.
• Statistically significant differences were observed for all measured parameters between VTE patients and controls.

Conclusions:

• The findings suggest that activated oxidative stress, iron dysregulation, and overproduction of hepcidin are associated with venous thrombosis.
• Iron dysregulation appears to contribute to oxidative stress, potentially promoting inflammation and a pro-thrombotic state in VTE.
• Oxidative stress and iron metabolism, including hepcidin regulation, represent promising targets for VTE risk assessment and management.