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Clinical Characteristics of Offspring Born to Parents with Type 2 Diabetes Diagnosed in Youth: Observations from

Jeanie B Tryggestad1, Megan M Kelsey2, Kimberly L Drews3

  • 1Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA.

Children (Basel, Switzerland)
|June 27, 2024
PubMed

Insights

Children exposed to type 2 diabetes in utero, especially from mothers in the TODAY study, face socioeconomic disadvantages and increased health risks. This highlights potential disparities for offspring of parents with youth-onset type 2 diabetes.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Public Health

Background:

  • Maternal diabetes during pregnancy impacts offspring health.
  • Limited data exists on in utero exposure to youth-onset type 2 diabetes.

Purpose of the Study:

  • To investigate health and socioeconomic factors in offspring exposed in utero to parental youth-onset type 2 diabetes within the TODAY study.

Main Methods:

  • Parental self-report questionnaires administered to participants of the Treatment Options for Type 2 Diabetes in Adolescent and Youth (TODAY) study.
  • Data collected on offspring demographics, health status (overweight, medication use), and educational needs (Individualized Education Plan).

Main Results:

  • Offspring of TODAY mothers experienced greater socioeconomic disadvantages (lower household income) compared to offspring of TODAY fathers.
  • Offspring of TODAY mothers showed higher rates of daily medication use and recidivism.
  • A significant percentage of offspring of TODAY mothers required an Individualized Education Plan.

Conclusions:

  • In utero exposure to youth-onset type 2 diabetes, particularly from mothers in the TODAY study, is associated with socioeconomic disadvantages.
  • Combined effects of in utero diabetes exposure and socioeconomic factors may increase offspring risk for health and educational disparities.

Keywords:
diabetesmedication useobesityperinatal complicationsrecidivism

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