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The Relationship between Seropositive Rheumatoid Arthritis and Congestive Heart Failure: A Nationwide Longitudinal

Yeo Song Kim1, Je Beom Hong2, Hakyung Kim3

  • 1Department of Neurosurgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

Journal of Personalized Medicine
|June 27, 2024
PubMed

Insights

Patients with seropositive rheumatoid arthritis (RA) have a significantly increased risk of developing congestive heart failure (CHF). This longitudinal study highlights the importance of monitoring cardiovascular health in RA patients.

Area of Science:

  • Rheumatology
  • Cardiology
  • Epidemiology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
  • Cardiovascular complications, including congestive heart failure (CHF), are a concern in RA patients.
  • The specific risk of CHF in seropositive RA populations requires further investigation.

Purpose of the Study:

  • To determine the association between seropositive rheumatoid arthritis (RA) and the risk of congestive heart failure (CHF).
  • To analyze the 12-year incidence of CHF in a nationwide Korean cohort with seropositive RA.

Main Methods:

  • A longitudinal cohort study using National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) data (2002-2015).
  • Defined seropositive RA by prescription of disease-modifying anti-rheumatic drugs (DMARDs) and ICD code M05.
  • Compared 2765 seropositive RA patients with 13,825 controls using Kaplan-Meier and Cox proportional hazards regression.

Main Results:

  • The adjusted hazard ratio for CHF in the seropositive RA group was 2.50 (95% CI: 1.45-4.30).
  • Increased CHF incidence rates were observed in seropositive RA females across different age groups, particularly in those without hypertension, diabetes, or dyslipidemia.
  • The risk of CHF was significantly elevated in the seropositive RA cohort.

Conclusions:

  • Seropositive rheumatoid arthritis is associated with a substantially increased risk of congestive heart failure.
  • These findings underscore the need for proactive cardiovascular risk assessment and management in patients with seropositive RA.
  • Further research may explore the underlying mechanisms linking RA and CHF.

Keywords:
congestive heart failureepidemiologypopulationseropositive rheumatoid arthritis

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