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Diagnostic Performance of F-18 FDG PET/CT in the Detection of Recurrent Colorectal Cancer: Correlation with Biochemical Markers and Conventional Imaging Modalities

  • 0Department of Nuclear Medicine, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
Journal of Clinical Medicine +

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June 27, 2024

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June 27, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

F-18 FDG PET/CT demonstrates high accuracy in detecting recurrent colorectal cancer (CRC), outperforming conventional imaging and tumor markers like CEA and CA 19-9. Routine integration of PET/CT is recommended for post-operative CRC surveillance in patients with elevated markers.

Area Of Science

  • Oncology
  • Nuclear Medicine
  • Radiology

Background

  • The diagnostic value of PET/CT for recurrent colorectal cancer (CRC) monitoring remains debated.
  • Elevated tumor markers (CEA, CA 19-9) and equivocal conventional imaging (CIM) findings often prompt further investigation.

Purpose Of The Study

  • To evaluate the diagnostic performance of F-18 FDG PET/CT in detecting recurrent CRC.
  • To compare PET/CT efficacy against CEA, CA 19-9 levels, and CIM.

Main Methods

  • Retrospective analysis of 134 CRC patients suspected of recurrence between 2009-2023.
  • Patients underwent F-18 FDG PET/CT based on elevated tumor markers and/or equivocal CIM.
  • Statistical analyses included univariate and multivariate assessments.

Main Results

  • PET/CT achieved high diagnostic performance (sensitivity 94.4%, specificity 82.5%, accuracy 87.3%) for recurrent CRC detection.
  • CEA showed high sensitivity (98.1%) but low specificity (15%) and accuracy (48.5%).
  • Multivariate analysis identified positive PET/CT, positive CIM, and elevated CA 19-9 as independent predictors of recurrence.

Conclusions

  • F-18 FDG PET/CT exhibits significant diagnostic efficacy for detecting CRC recurrence.
  • PET/CT should be routinely incorporated into post-operative surveillance for CRC patients with elevated tumor markers.

Keywords:

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