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Transition-Metal-Oxide-Based Nanozymes for Antitumor Applications
Huilin Sun1, Yang Bai1, Donghui Zhao1
1School of Pharmacy, Changzhou University, Changzhou 213164, China.
Materials (Basel, Switzerland)
|June 27, 2024
Summary
Transition metal oxide nanozymes show promise for cancer treatment by regulating the tumor microenvironment. This review summarizes their enzymatic activities, metal ions, and future challenges for nanomedicine.
Area of Science:
- Nanomedicine
- Biochemistry
- Materials Science
Background:
- Transition metal oxide (TMO) nanozymes offer unique catalytic properties for antitumor applications.
- They can modulate the tumor microenvironment (TME) by altering reactive oxygen species (ROS) and glutathione (GSH) levels.
Purpose of the Study:
- To provide an overview of recent advancements in TMO-based nanozymes for cancer therapy.
- To focus on their enzymatic activities, the roles of specific metal ions, and innovative designs.
Main Methods:
- Literature review of TMO-based nanozymes.
- Analysis of their enzymatic activities (catalase, peroxidase, superoxide dismutase, oxidase, glutathione oxidase-like).
- Summary of commonly studied transition metals (Fe, Mn, Cu, Ce) and multimetallic oxides.
Main Results:
- TMO nanozymes exhibit diverse enzymatic activities crucial for TME modulation.
- Fe, Mn, Cu, and Ce are key metals in TMO nanozyme development.
- Innovative designs showcase multifunctional capabilities for cancer treatment.
Conclusions:
- TMO-based nanozymes hold significant promise for nanomedicine and improved cancer therapy.
- Further research is needed to address challenges in biosafety, targeting, and mechanistic understanding.
