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Related Experiment Video

Updated: Jun 22, 2025

Polymeric Microneedle Array Fabrication by Photolithography
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Optical Microneedle-Lens Array for Selective Photothermolysis.

Jongho Park1, Kotaro Shobayashi2, Beomjoon Kim1

  • 1Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan.

Micromachines
|June 27, 2024
PubMed
Summary

Researchers developed a gold-coated optical microneedle-lens array (OMLA) to improve laser therapy. This device enhances photothermal therapy by precisely delivering light energy to targeted skin layers, overcoming challenges like limited light penetration and melanin absorption.

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Area of Science:

  • Biomedical Engineering
  • Optical Engineering
  • Dermatology

Background:

  • Photothermolysis converts light to heat for targeted tissue destruction.
  • Laser therapy utilizes photothermolysis for treating skin conditions like cancer and port-wine stains.
  • Current limitations include poor light penetration and melanin absorption in skin.

Purpose of the Study:

  • To propose and develop an optical microneedle-lens array (OMLA) for enhanced photothermal therapy.
  • To overcome challenges of light penetration and melanin absorption in laser treatments.
  • To improve the efficiency and precision of laser therapy for skin diseases.

Main Methods:

  • Developed a novel frame-guided micromolding technique for OMLA fabrication.
  • Coated the OMLA with gold to enhance light delivery.
Keywords:
laser therapylens arraylocalized light deliverymicroneedleopticalphotothermolysisselective

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  • Assembled the OMLA using two negative molds with simultaneous alignment.
  • Evaluated the optical and heat transfer characteristics of the OMLA.

    • Main Results:

    • Successfully fabricated a gold-coated OMLA using the novel micromolding method.
    • Demonstrated the OMLA's capability for precise light delivery to targeted skin layers.
    • Showcased potential for overcoming light penetration and melanin absorption issues.
    • Evaluated optical and thermal properties, confirming suitability for photothermal applications.

    Conclusions:

    • The developed gold-coated OMLA offers a promising solution for improving laser photothermal therapy.
    • This technology enables precise photon delivery, enhancing treatment efficiency and safety.
    • The OMLA is expected to play a significant role in advancing laser-based treatments for various skin conditions.