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A High-Aspect-Ratio Deterministic Lateral Displacement Array for High-Throughput Fractionation.

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Deterministic lateral displacement (DLD) devices can now fractionate microparticles at high throughputs. This breakthrough enables new industrial applications in chemical, pharmaceutical, and recycling technologies by achieving nearly 1 L/hr flow rates.

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deterministic lateral displacement (DLD)high aspect ratiohigh throughputmicrofluidicssize-dependent fractionation

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Area of Science:

  • Microfluidics
  • Biotechnology
  • Chemical Engineering

Background:

  • Industrial applications of microparticle fractionation using deterministic lateral displacement (DLD) are limited by low throughput.
  • High-volume flow necessitates investigating high flow velocities and aspect ratios in DLD devices.
  • Experimental data on DLD fractionation of sub-10 µm particles at Reynolds numbers above 60 and aspect ratios above 4:1 is lacking.

Purpose of the Study:

  • To investigate high throughput microparticle fractionation using deterministic lateral displacement (DLD) devices.
  • To develop and test DLD devices with high aspect ratios for enhanced flow rates.
  • To enable new industrial applications in chemical, pharmaceutical, and recycling sectors.

Main Methods:

  • Developed a microfabrication process using deep reactive ion etching of silicon and anodic bonding for high aspect ratio (6:1) DLD devices.
  • Utilized simulations and experimental fractionation of polystyrene particle suspensions.
  • Investigated particle fractionation at flow rates up to 15 mL/min (Reynolds numbers up to 90).

Main Results:

  • Successfully fabricated and tested DLD devices with a 6:1 aspect ratio.
  • Achieved successful fractionation of 2 µm with 10 µm and 5 µm with 10 µm particle mixtures at high flow rates (up to Re=90).
  • Attained an unprecedented microparticle fractionation throughput of nearly 1 L/hr.

Conclusions:

  • High aspect ratio DLD devices enable significantly higher throughputs for microparticle fractionation.
  • The developed DLD technology overcomes previous limitations, paving the way for industrial-scale applications.
  • This advancement opens new possibilities in chemical, pharmaceutical, and recycling industries.