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Combination therapy with isosorbide dinitrate: current status and the future.

J S Schroeder

    American Heart Journal
    |July 1, 1985
    PubMed
    Summary
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    Isosorbide dinitrate (ISDN) offers proven safety and efficacy for angina, hypertension, and heart failure. Further research into combination therapy with ISDN may enhance patient outcomes.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Isosorbide dinitrate (ISDN) has a 25-year history of demonstrated safety and efficacy in treating cardiovascular conditions.
    • Combination therapy is clinically accepted for maximizing therapeutic effects and minimizing side effects in antianginal treatment.

    Purpose of the Study:

    • To explore the potential benefits of combining ISDN with other antianginal agents and calcium antagonists.
    • To identify further clinical research areas for ISDN in cardiovascular and noncardiovascular conditions.

    Main Methods:

    • Review of existing clinical studies on ISDN monotherapy and combination therapy.
    • Discussion of the challenges in designing clinical trials for combination therapies.

    Main Results:

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  • ISDN is a safe and effective agent for angina, hypertension, and congestive heart failure.
  • Combination therapy with ISDN is a promising strategy for improved patient outcomes.

    • Conclusions:

    • Further clinical research into ISDN combination therapy is warranted for angina pectoris, hypertension, and congestive heart failure.
    • ISDN may also be beneficial for noncardiovascular smooth muscle disorders like esophageal spasm.