Bioactive Peptides from Meretrix lusoria Enzymatic Hydrolysate as a Potential Treatment for Obesity in db/db Mice
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View abstract on PubMed
Summary
This summary is machine-generated.Marine bioactive peptides from <i>Meretrix lusoria</i> (MLP) effectively reduced obesity and improved diabetes in mice. MLP treatment lowered body weight, improved lipid profiles, and enhanced glucose tolerance by activating the AMPK pathway.
Area Of Science
- Marine biology and biochemistry
- Nutraceuticals and functional foods
- Metabolic disease research
Background
- Obesity is a major risk factor for cardiovascular disease, inflammation, and diabetes.
- Marine bioactive peptides show potential as anti-obesity agents by regulating adipocyte differentiation via the AMPK signaling pathway.
Purpose Of The Study
- To investigate the anti-obesity and anti-diabetic effects of a <i>Meretrix lusoria</i> Protamex enzymatic hydrolysate (MLP) fraction (≤1 kDa).
- To evaluate MLP's impact on metabolic parameters and the AMPK signaling pathway in <i>db/db</i> mice.
Main Methods
- A 6-week treatment of leptin receptor-deficient <i>db/db</i> mice with MLP (150 mg/kg or 300 mg/kg daily).
- Assessment of body weight, serum lipid profiles, hepatic markers, glucose tolerance, and hepatic antioxidant enzyme activities.
- Histological analysis of liver and epididymal fat.
- Western blot analysis for AMPK protein expression and lipogenic gene expression.
Main Results
- MLP treatment significantly reduced body weight, serum total cholesterol, triglycerides, and LDL-cholesterol.
- MLP decreased hepatic steatosis and epididymal fat, improved glucose tolerance, and elevated hepatic antioxidant enzyme activities.
- Increased AMPK protein expression and decreased lipogenic gene expression were observed in MLP-treated mice.
Conclusions
- Bioactive peptides from <i>Meretrix lusoria</i> (MLP) demonstrate significant anti-obesity and anti-diabetic effects in <i>db/db</i> mice.
- MLP acts, in part, by activating the AMPK signaling pathway, regulating lipid metabolism, and adipogenesis.
- These findings suggest MLP's potential as a functional food additive or pharmaceutical for managing obesity and diabetes.
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