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Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC Crosslinking of Small Molecules to Isolate Chromatin

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Click Chemistry in Polymersome Technology.

Nuno M Saraiva^1,2, Ana Alves^3,4, Paulo C Costa^3,4

¹LQOF-Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.

Pharmaceuticals (Basel, Switzerland)

|June 27, 2024

Summary

Polymersomes, versatile nanovesicles, are enhanced by click chemistry for advanced drug delivery and diagnostics. This review details their synthesis and functionalization using copper [I]-catalyzed azide-alkyne cycloaddition (CuAAC).

Keywords:

CuAAC click chemistry copolymer synthesis polymersome surface modification

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Area of Science:

Nanotechnology
Polymer Chemistry
Bioconjugation

Background:

Polymersomes are self-assembled nanoparticles from amphiphilic block copolymers.
They show promise in drug delivery, medical imaging, and diagnostics.
Functionalization is key to expanding their applications.

Purpose of the Study:

To review the synergistic combination of polymersomes and click chemistry.
To highlight advancements in polymersome synthesis and functionalization.
To showcase applications enabled by this integration.

Main Methods:

Incorporation of azide and alkyne functional groups into polymer building blocks.
Utilizing copper [I]-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation.
Surface modification and ligand conjugation strategies.

Main Results:

Click chemistry significantly enhances polymersome functionalization and bioconjugation.
Diverse click reactions enable tailored synthesis and surface modification.
Examples of advanced polymersome applications are presented.

Conclusions:

The combination of polymersomes and click chemistry offers powerful tools for nanomedicine.
This synergistic approach facilitates the development of targeted drug delivery systems.
Continued exploration promises further innovation in diagnostics and imaging.