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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming
Stanislav Boychenko1, Vera S Egorova2, Andrew Brovin1
1Gene Therapy Department, Center for Translational Medicine, Sirius University of Science and Technology, 354340 Sirius, Russia.
Pharmaceuticals (Basel, Switzerland)
|June 27, 2024
Summary
Obesity is a global pandemic. This study explores converting white fat cells to beige cells, enhancing thermogenesis and lipolysis to combat obesity and insulin resistance.
Area of Science:
- Metabolic research
- Adipose tissue biology
- Obesity research
Background:
- Obesity affects over half a billion people globally, stemming from genetic, behavioral, and environmental factors.
- White adipose tissue stores energy, while brown adipose tissue generates heat via UCP1 gene expression.
- White adipocytes can transdifferentiate into thermogenic 'beige' adipocytes.
Purpose of the Study:
- To review strategies for white-to-beige adipocyte conversion.
- To discuss adipose tissue catabolic re-activation.
- To explore non-shivering thermogenesis for obesity treatment.
Main Methods:
- Literature review on adipocyte transdifferentiation.
- Analysis of molecular mechanisms in thermogenesis.
- Discussion of therapeutic approaches in medicinal chemistry and gene therapy.
Main Results:
- White-to-beige adipocyte conversion activates thermogenesis and lipolysis.
- Targeting adipose tissue metabolism offers potential obesity interventions.
- Drug development focuses on insulin resistance and obesity.
Conclusions:
- White-to-beige conversion is a promising strategy for obesity management.
- Re-activating adipose tissue catabolism can counteract obesity.
- Further research into thermogenesis holds therapeutic potential.
Keywords:
PPAR gammaadipogenesisadipose browningadipose tissueanti-obesityaryl hydrocarbon receptorendocrine disruptorsphytochemicalsthermogenesistranscription factorsMore Related Videos
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