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Assembled pH-Responsive Gastric Drug Delivery Systems Based on 3D-Printed Shells.
Haoye Bei1, Pingping Zhao1, Lian Shen1
1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Pharmaceutics
|June 27, 2024
Summary
This study presents a novel 3D-printed gastric delivery system using pH-responsive modular units for smart stomach disease treatment. The system self-regulates pH and delivers drugs effectively, offering personalized therapy for acid-related disorders.
Area of Science:
- Biomedical Engineering
- Materials Science
- Gastroenterology
Background:
- Gastric acid secretion is crucial in stomach diseases like gastritis and ulcers, but its complex regulation complicates treatment.
- Current real-time detection and control of gastric acid are challenging and costly.
- Smart gastric delivery systems responding to low pH offer potential for personalized stomach disease management.
Purpose of the Study:
- To develop and evaluate a 3D-printed, pH-responsive modular gastric delivery system for self-regulation of stomach pH and targeted drug delivery.
- To demonstrate the system's capability for personalized treatment of stomach diseases.
- To explore the advantages of 3D printing for creating complex drug delivery systems.
Main Methods:
- Assembly of modular devices using pH-responsive units with a 50 mm² release window.
- Utilizing downward floatation and internal gas production for pH self-regulation within 10 minutes.
- Loading devices with antacids and acid suppressors for drug release studies.
- Employing 3D printing for fabricating multi-level drug delivery systems with adjustable structures.
Main Results:
- The modular units demonstrated rapid pH response and self-regulation.
- Assembled devices exhibited stable downward floatation and sequential detachment.
- Devices successfully achieved smart pH self-regulation under simulated physiological and pathological conditions.
- Drug-loaded devices provided multi-pulse or prolonged release of antacids and acid suppressors post-neutralization.
Conclusions:
- 3D printing enables flexible fabrication of complex, multi-level gastric drug delivery systems.
- The developed pH-responsive system offers a universal and adaptable strategy for personalized treatment of gastric acid-related disorders.
- This technology is particularly promising for delivering acid-unstable drugs in the stomach.
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