Antitumoral-Embedded Biopolymeric Spheres for Implantable Devices.

Area of Science:

• Biomaterials Science
• Nanotechnology
• Drug Delivery Systems

Background:

• Surface modification of implantable devices is crucial for personalized healthcare.
• Biocompatible coatings enhance patient outcomes and reduce side effects.
• Developing tunable coatings with therapeutic properties is an ongoing challenge.

Purpose of the Study:

• To evaluate composite coatings made of poly(lactide-co-glycolide) (PLGA) spheres containing hydroxyapatite (HA) and methotrexate (MTX).
• To assess the drug release profile and biomineralization capabilities of these PLGA/HA-MTX coatings.
• To compare the biocompatibility and cellular response of the composite coatings against pristine titanium.

Main Methods:

• Fabrication of composite coatings using PLGA spheres embedded with HA and MTX.
• In vitro bio-simulated testing for up to one week.
• Assessment of drug release kinetics and biomineralization.
• Evaluation of cell adhesion and proliferation using human preosteoblast and osteosarcoma cell lines.

Main Results:

• Gradual release of methotrexate (antitumor drug) was observed over one week.
• The PLGA/HA-MTX coatings demonstrated significant biomineralization potential.
• Superior biocompatibility was evident compared to pristine titanium.
• Enhanced cell adhesion and proliferation were observed on the composite coatings.

Conclusions:

• Composite coatings of PLGA/HA-MTX spheres offer a promising approach for bioactive surface modification of implants.
• These coatings facilitate controlled drug release and promote osteointegration.
• The enhanced biocompatibility and cellular response suggest potential for improved clinical outcomes in personalized medicine.