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MOF-Based Platform for Kidney Diseases: Advances, Challenges, and Prospects.
Li-Er Deng1, Manli Guo2, Yijun Deng2
1Department of Nephrology, Dongguan Traditional Chinese Medicine Hospital, Dongguan 523000, China.
Pharmaceutics
|June 27, 2024
Summary
Metal-organic frameworks (MOFs) show significant promise for diagnosing and treating kidney diseases. These advanced materials can act as biosensors for early detection and as therapeutic agents for toxin removal and drug delivery.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Kidney diseases are a leading global cause of death, posing significant clinical challenges.
- Current diagnostic and treatment technologies for renal illness are insufficient to meet clinical needs.
- Metal-organic frameworks (MOFs) offer novel solutions for kidney disease management.
Purpose of the Study:
- To review recent advancements in the application of MOFs for kidney disease diagnosis and treatment.
- To elucidate the fundamental properties and structures of MOFs relevant to renal applications.
- To explore the potential of MOFs in addressing unmet clinical needs in nephrology.
Main Methods:
- Literature review of research on MOFs in kidney disease diagnosis and treatment.
- Analysis of MOF design principles for biosensing applications.
- Evaluation of MOFs as adsorbents for uremic toxins and drug delivery systems.
Main Results:
- MOFs function as sensitive biosensors for detecting kidney disease biomarkers.
- MOFs serve as effective adsorbents for removing uremic toxins during hemodialysis.
- MOFs enable precise drug delivery and can address trace element imbalances in kidney disease.
Conclusions:
- MOFs demonstrate versatile applications in both the diagnosis and treatment of kidney diseases.
- Further research into MOFs holds significant potential for improving patient outcomes.
- Challenges and future prospects of MOFs in nephrology require continued investigation.
