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Related Concept Videos

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Related Experiment Video

Updated: Apr 24, 2026

Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
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Novel Hydrogels Based on the Nano-Emulsion Formulation Process: Development, Rheological Characterization, and Study

Usama Jamshaid1,2, Nicolas Anton1, Mohamed Elhassan1,3

  • 1INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS, Université de Strasbourg, F-67000 Strasbourg, France.

Pharmaceutics
|June 27, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed novel polymer-free nanoemulgels using only nonionic surfactants, oil, and water. These promising systems offer a simple one-step formulation for encapsulating and delivering diverse molecules.

Keywords:
hydrogelnano-emulsionrheologysol/gel transitionternary system

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Area of Science:

  • Materials Science
  • Colloid and Surface Chemistry

Background:

  • Traditional hydrogels often rely on polymers, which can complicate formulation and biocompatibility.
  • Emulsion-based gel formulations typically involve complex, multi-step processes.

Purpose of the Study:

  • To introduce a novel polymer-free hydrogel system (nanoemulgels) created from nonionic surfactants, oil, and water.
  • To investigate the formation, properties, and potential applications of these nanoemulgels for molecular encapsulation and delivery.

Main Methods:

  • Utilizing a spontaneous emulsification-inspired process for a simple, one-step formulation.
  • Employing oscillatory rheological characterization to study gel formation, sol/gel transitions, and gel strength.
  • Monitoring the release profile of an encapsulated hydrophilic model molecule.

Main Results:

  • Successfully formed polymer-free hydrogels (nanoemulgels) from nonionic surfactants, oil, and water.
  • Characterized the gelation process, demonstrating control over sol/gel transitions and gel strength.
  • Investigated the encapsulation and release of a hydrophilic molecule, correlating release profiles with rheological properties.

Conclusions:

  • The developed nanoemulgels represent a novel and promising class of polymer-free hydrogels.
  • The simple one-step formulation process offers an advantage over traditional methods.
  • These systems demonstrate potential for encapsulating and delivering molecules with varying solubilities, with release influenced by gel properties.