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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Xanthan-Polyurethane Conjugates: An Efficient Approach for Drug Delivery.

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New topical drug delivery systems using xanthan and polyurethane matrices successfully incorporated antifungal ketoconazole and anti-inflammatory piroxicam. These biomaterials demonstrated antimicrobial effectiveness and controlled drug release, showing promise for pharmaceutical applications.

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biomedical Engineering

Background:

  • Development of effective topical drug delivery systems is crucial for localized treatment.
  • Ketoconazole (antifungal) and piroxicam (anti-inflammatory) are key therapeutic agents.
  • Xanthan and polyurethane offer potential as biocompatible matrix materials.

Purpose of the Study:

  • To develop and characterize novel topical drug delivery systems incorporating ketoconazole and piroxicam.
  • To evaluate the mechanical properties and drug release kinetics of xanthan-polyurethane matrices.
  • To assess the antimicrobial efficacy and drug release profiles of modified and unmodified xanthan-PU systems.

Main Methods:

  • Incorporation of ketoconazole and piroxicam into xanthan and oleic acid-esterified xanthan-polyurethane matrices.
  • Mechanical testing (compressive stress, resilience, strength, peak sustainable strain).
  • Drug release kinetics analysis using the Weibull model; assessment of antimicrobial effectiveness.

Main Results:

  • Drug incorporation enhanced matrix compressive resilience and altered compressive strength and peak sustainable strain.
  • Weibull model best described drug release kinetics; oleic acid-esterified xanthan-PU showed slower release.
  • All developed materials exhibited antimicrobial effectiveness; higher piroxicam release from modified xanthan-PU.

Conclusions:

  • Polyurethane-xanthan matrices, both modified and unmodified, show significant potential as topical drug delivery systems.
  • These systems facilitate controlled release of ketoconazole and piroxicam with demonstrated antimicrobial activity.
  • Material modification influences mechanical properties and drug release rates, offering tunable delivery options.