Related Experiment Video
Updated: Jun 22, 2025

Nasal Wipes for Influenza A Virus Detection and Isolation from Swine
Published on: December 4, 2015
Genetic Variations of African Swine Fever Virus: Major Challenges and Prospects
Shengmei Chen1,2, Tao Wang2, Rui Luo2
1College of Life Science and Engineering, Foshan University, Foshan 528231, China.
Abstract:
African swine fever (ASF) is a contagious viral disease affecting pigs and wild boars. It typically presents as a hemorrhagic fever but can also manifest in various forms, ranging from acute to asymptomatic. ASF has spread extensively globally, significantly impacting the swine industry. The complex and highly variable character of the ASFV genome makes vaccine development and disease surveillance extremely difficult. The overall trend in ASFV evolution is towards decreased virulence and increased transmissibility. Factors such as gene mutation, viral recombination, and the strain-specificity of virulence-associated genes facilitate viral variations. This review deeply discusses the influence of these factors on viral immune evasion, pathogenicity, and the ensuing complexities encountered in vaccine development, disease detection, and surveillance. The ultimate goal of this review is to thoroughly explore the genetic evolution patterns and variation mechanisms of ASFV, providing a theoretical foundation for advancement in vaccine and diagnostic technologies.
Related Concept Videos
Viral Mutations
Viral Recombination
Genetic Variation
Genes exist in different versions called alleles,...
Mutation, Gene Flow, and Genetic Drift

