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A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Missed Opportunities: A Retrospective Study of Hepatitis C Testing in Hospital Inpatients
Christine Roder1,2, Carl Cosgrave3, Kathryn Mackie4,5
1Barwon South West Public Health Unit, Barwon Health, Geelong 3220, Australia.
Insights
Hepatitis C testing is crucial for elimination. This study found many patients with hepatitis C risk factors in hospitals were not tested, indicating missed opportunities for care and treatment.
Area of Science:
- Hepatology
- Public Health
- Infectious Diseases
Background:
- Achieving hepatitis C elimination requires increased testing among at-risk populations.
- Hospitals present opportunities for hepatitis C screening and linkage to care.
- Identifying gaps in the hepatitis C testing cascade is essential for improving care.
Purpose of the Study:
- To evaluate the hepatitis C testing cascade for patients with indications for testing at a regional hospital in Victoria, Australia.
- To identify missed opportunities in hepatitis C care among hospital inpatients and emergency department attendees.
- To determine predictors of hepatitis C care engagement, including testing and treatment.
Main Methods:
- Retrospective study of adult hospital inpatients and emergency department attendees from 2018-2021.
- Inclusion criteria: indications for intravenous drug use (IDU) or hepatitis C diagnosis.
- Data sources included hospital admissions, pathology, pharmacy, and outpatient records. Logistic regression was used to analyze predictors of care.
Main Results:
- Of 79,923 adult admissions, 1345 (1.7%) had IDU codes and 628 (0.8%) had hepatitis C codes (N=1892).
- Hepatitis C virus (HCV) status remained unknown for 1569 (82.9%) patients at study end.
- Emergency department admissions were linked to a 3.29-fold increased odds of not receiving hepatitis C care.
Conclusions:
- Over 2% of inpatients had indications for hepatitis C testing, yet most were not tested during their hospital contact.
- Significant opportunities for hepatitis C testing and linkage to care are being missed within hospital settings.
- Integrating hepatitis C testing and linkage strategies into hospital departments with high-risk populations is vital for regional elimination efforts.
Abstract:
Increasing testing is key to achieving hepatitis C elimination. This retrospective study aimed to assess the testing cascade of patients at a regional hospital in Victoria, Australia, who inject drugs or are living with hepatitis C, to identify missed opportunities for hepatitis C care. Adult hospital inpatients and emergency department (ED) attendees from 2018 to 2021 with indications for intravenous drug use (IDU) or hepatitis C on their discharge or ED summary were included. Data sources: hospital admissions, pathology, hospital pharmacy, and outpatients. We assessed progression through the testing cascade and performed logistic regression analysis for predictors of hepatitis C care, including testing and treatment. Of 79,923 adults admitted, 1345 (1.7%) had IDU-coded separations and 628 (0.8%) had hepatitis C-coded separations (N = 1892). Hepatitis C virus (HCV) status at the end of the study was unknown for 1569 (82.9%). ED admissions were associated with increased odds of not providing hepatitis C care (odds ratio 3.29, 95% confidence interval 2.42-4.48). More than 2% of inpatients at our hospital have an indication for testing, however, most are not being tested despite their hospital contact. As we work toward HCV elimination in our region, we need to incorporate testing and linkage strategies within hospital departments with a higher prevalence of people at risk of infection.
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