Association between dinner-bedtime interval and type 2 diabetes mellitus: a large-scale cross-sectional study

Area of Science:

• Metabolic Health
• Chronobiology
• Epidemiology

Background:

• Circadian disruption impacts glucose metabolism.
• The dinner-bedtime interval (DBI) serves as an indicator of circadian clock alignment.
• Investigating the link between DBI and type 2 diabetes mellitus (T2DM) is crucial for public health.

Purpose of the Study:

• To examine the association between the dinner-bedtime interval (DBI) and type 2 diabetes mellitus (T2DM).
• To identify factors influencing DBI.
• To assess the potential of DBI as a preventive measure for T2DM.

Main Methods:

• Analysis of demographic and lifestyle data from 7676 adult subjects.
• Collection of fasting blood samples for biochemical analysis.
• Application of generalized linear regression and logistic regression with restricted cubic splines to evaluate DBI and T2DM association.

Main Results:

• Age, female sex, higher education, increased income, moderate physical activity, current smoking, and current drinking were correlated with DBI.
• A significant association was found between DBI and T2DM (adjusted OR: 0.910).
• A DBI longer than 3 hours was associated with a decreased risk of T2DM (adjusted OR: 0.773).

Conclusions:

• A dinner-bedtime interval (DBI) exceeding 3 hours demonstrates a beneficial effect in preventing type 2 diabetes mellitus (T2DM).
• Further research is warranted to confirm these findings and elucidate the underlying mechanisms.
• DBI represents a modifiable lifestyle factor with potential implications for T2DM prevention strategies.