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Three candidate SNPs show associations with thyroid-stimulating hormone in euthyroid subjects: Tehran thyroid study
Azita Zadeh-Vakili1, Leila Najd-Hassan-Bonab2, Mahdi Akbarzadeh2
1Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
This study found specific gene variants associated with thyroid stimulating hormone (TSH) levels in an Iranian population. These genetic factors contribute to variations in thyroid function, confirming findings from other ethnic groups.
Area of Science:
- Endocrinology
- Genetics
- Population Health
Background:
- Interindividual variation in free thyroxine (FT4) and thyroid stimulating hormone (TSH) levels is influenced by genetic factors.
- Genome-wide association studies have identified numerous variants associated with thyroid function.
Purpose of the Study:
- To investigate the association of candidate genetic variants with FT4 and TSH serum levels in a euthyroid Iranian population.
- To explore the impact of single nucleotide polymorphisms (SNPs) on thyroid hormone levels using an additive genetic model.
Main Methods:
- Analysis of 2931 unrelated euthyroid subjects from the Tehran Thyroid Study (TTS).
- Genotyping and statistical analysis to examine the association of selected SNPs with FT4 and TSH.
- Haplotype analysis to evaluate regional associations with thyroid hormone levels.
Main Results:
- A significant association was found between the rs4338740-C allele and TSH levels (P=0.0004).
- SNPs rs4954192 (ACMSD) and rs4445669 (CADM1) correlated with normal TSH levels (P=0.011 and P=0.014, respectively).
- Two haplotypes, ACGA and AC, were significantly associated with TSH levels in euthyroid individuals.
Conclusions:
- This is the first genetic association study of TSH and FT4 reference values in an Iranian population.
- The findings suggest that certain gene variants influencing TSH levels in other populations are also relevant in Iranians.
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