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Thymic factor therapy for herpetic keratitis.

P Pivetti-Pezzi, P De Liso, S Tamburi

    Annals of Ophthalmology
    |June 1, 1985
    PubMed
    Summary
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    Thymostimulin significantly reduced herpetic keratitis recurrence and improved corneal healing in a 24-month trial. This immunomodulator also increased immune cell activity, showing promise for managing herpetic eye disease.

    Area of Science:

    • Ophthalmology
    • Immunology

    Background:

    • Herpetic keratitis is a recurrent viral infection of the cornea.
    • Recurrences can lead to vision loss and require effective management strategies.

    Purpose of the Study:

    • To evaluate the efficacy and safety of thymostimulin in managing herpetic keratitis.
    • To assess the impact of thymostimulin on recurrence rates and corneal healing.

    Main Methods:

    • A 24-month, double-blind, placebo-controlled trial involving 30 patients with herpetic keratitis.
    • Patients received either local treatment plus placebo or local treatment plus thymostimulin (TS).
    • Evaluated recurrence rates, immune cell counts (E rosette), and corneal re-epithelialization time.

    Main Results:

    Related Experiment Videos

    • Thymostimulin significantly reduced the recurrence rate of herpetic keratitis compared to placebo.
    • Patients treated with thymostimulin showed a significant increase in sheep rosette-forming cells (E rosette).
    • Thymostimulin accelerated corneal re-epithelialization in patients with superficial keratitis.

    Conclusions:

    • Thymostimulin demonstrates safety and efficacy in managing herpetic keratitis.
    • It may be a beneficial adjunct therapy for reducing recurrences and promoting corneal healing.
    • The drug's immunomodulatory effects, indicated by increased E rosette, may contribute to its therapeutic benefits.