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Cognitive dysfunction in diabetes-related foot complications: A cohort study
Mai Loan Nguyen1, Dana Wong1, Elizabeth Barson2
1School of Psychology and Public Health, La Trobe University, Bundoora, VIC 3086 Australia.
Journal of Diabetes and Metabolic Disorders
|June 27, 2024
Summary
Cognitive impairment is common in diabetes, especially with foot complications (DRFC). People with DRFC show significant deficits in memory and executive functions, impacting self-management and requiring targeted interventions.
Area of Science:
- Neuroscience
- Endocrinology
- Psychology
Background:
- Diabetes mellitus is associated with mild-moderate cognitive impairment.
- Diabetes-related foot complications (DRFC) may exacerbate cognitive decline.
- Cognitive deficits can hinder diabetes self-management and treatment adherence.
Purpose of the Study:
- To characterize cognitive function in individuals with DRFC.
- To identify specific cognitive domains affected by DRFC.
- To explore factors associated with cognitive impairment in DRFC.
Main Methods:
- Cross-sectional cohort study of 80 adults with DRFC.
- Administered a comprehensive cognitive battery assessing memory, attention, and executive functions.
- Compared participant performance to age-matched population norms.
Main Results:
- DRFC participants demonstrated significantly poorer performance on most cognitive tasks compared to norms.
- Largest deficits observed in inhibition control, verbal memory, abstract reasoning, and working memory.
- Poorer cognitive function linked to lower education, male gender, higher HbA1c, and vascular complications.
Conclusions:
- Individuals with DRFC exhibit marked reductions in cognitive functioning, particularly verbal memory and executive functions.
- Factors like lower education, male gender, and diabetes severity increase the risk of cognitive impairment.
- Addressing cognitive barriers is crucial for optimizing self-management and outcomes in DRFC patients.
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