RISK FACTORS FOR ACUTE KIDNEY INJURY ASSOCIATED WITH SEVERE HYPOTHYROIDISM.

Area of Science:

• Endocrinology
• Nephrology
• Internal Medicine

Background:

• Severe hypothyroidism is a complex endocrine disorder.
• Acute kidney injury (AKI) is a potential complication in patients with severe hypothyroidism.
• Understanding AKI predictors in this population is crucial for timely intervention.

Purpose of the Study:

• To identify factors associated with the development of AKI in patients experiencing severe hypothyroidism.
• To analyze the relationship between demographic, clinical, and biochemical markers and AKI incidence.

Main Methods:

• Retrospective observational study of 100 patients with severe hypothyroidism (TSH > 50 mIU/L).
• Logistic regression analysis was employed to determine predictors of AKI.
• Data collected between January 2015 and April 2021.

Main Results:

• Hypothyroidism diagnosed after age 60 (OR 59.674), free triiodothyronine (FT3) < 1.3 pg/mL (OR 17.151), and creatine kinase (CK) > 1000 U/L (OR 1.522) were significant predictors of AKI.
• The AKI group was older and had a higher male-to-female ratio compared to the control group.
• A total of 20 patients developed AKI.

Conclusions:

• Patients diagnosed with severe hypothyroidism after age 60, with FT3 < 1.3 pg/mL, or CK > 1000 U/L face an elevated risk of AKI.
• Close monitoring and follow-up are recommended for these high-risk individuals.
• Early identification of these risk factors can guide preventative strategies for AKI in severe hypothyroidism.