THE CLINICAL SIGNIFICANCE OF COMPLETE BLOOD COUNT, NEUTROPHIL-TO-LYMPHOCYTE RATIO, AND MONOCYTE-TO-LYMPHOCYTE RATIO
1Obstetrical Department, Fu Yang People's Hospital Affiliated to Anhui Medical University, Anhui FuYang, China.
Acta Endocrinologica (Bucharest, Romania : 2005)
|June 27, 2024
Summary
Inflammatory factors like white blood cell (WBC) counts and monocyte (MON) levels are linked to gestational diabetes mellitus (GDM). Monocyte levels showed the highest diagnostic value in identifying GDM risk during early pregnancy.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Immunology
Background:
- Gestational diabetes mellitus (GDM) is a significant pregnancy complication.
- Inflammation plays a role in the development of GDM.
- Complete blood count (CBC) components and inflammatory ratios are potential biomarkers.
Purpose of the Study:
- To investigate the association between inflammatory factors and GDM.
- To evaluate CBC components, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) in GDM prediction.
Main Methods:
- A cohort of 635 pregnant women with GDM and 296 controls were analyzed.
- Comprehensive CBC parameters, inflammatory ratios (NLR, MLR, PLR), and liver enzymes were assessed.
- Receiver operating characteristic (ROC) curve analysis was employed to determine diagnostic efficacy.
Main Results:
- Significant differences in WBC, neutrophil (NEU), lymphocyte (LYM), monocyte (MON), RBC, HGB, PCT, ALT, AST, GGT, NLR, and MLR were observed between GDM and control groups (P<0.05).
- Monocyte (MON) levels demonstrated the highest diagnostic accuracy among all assessed factors.
- Several inflammatory markers showed a correlation with GDM development.
Conclusions:
- Inflammatory factors, including WBC, NEU, LYM, MON, NLR, and MLR counts, are significantly correlated with GDM.
- Monocyte levels are a promising biomarker for early GDM screening.
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