A COMPREHENSIVE EVALUATION OF HEMOGRAM-DERIVED INFLAMMATORY INDICES IN HASHIMOTO THYROIDITIS AND NON-IMMUNOGENIC...

Area of Science:

• Endocrinology
• Immunology
• Clinical Diagnostics

Background:

• Thyroid disorders, including Hashimoto's thyroiditis (HT) and non-immunogenic hypothyroidism (NIH), are associated with inflammatory processes.
• Inflammatory markers such as the Systemic Inflammation Index (SII), Platelet to Lymphocyte Ratio (PLR), and Neutrophil to Lymphocyte Ratio (NLR) are increasingly recognized for their potential diagnostic utility.

Purpose of the Study:

• To evaluate the Systemic Inflammation Index (SII), Platelet to Lymphocyte Ratio (PLR), and Neutrophil to Lymphocyte Ratio (NLR) in patients with HT and NIH.
• To assess the diagnostic value of these inflammatory indices in predicting the presence of inflammation in thyroid conditions.

Main Methods:

• Retrospective review of records from 505 patients, including 190 healthy controls, 166 euthyroid HT, 91 hypothyroid HT, and 58 NIH patients.
• Analysis of SII, PLR, and NLR values across different patient groups and controls.

Main Results:

• Significant differences in SII, PLR, and NLR were observed between patient groups (HT and NIH) and healthy controls (p<0.001 for SII and PLR, p=0.007 for NLR).
• SII and PLR showed significant differences when comparing subgroups (euthyroid HT, hypothyroid HT, NIH) to controls (p<0.001).
• No significant differences in SII, PLR, or NLR were found between the HT and NIH subgroups themselves.

Conclusions:

• The study confirms elevated levels of PLR, NLR, and SII in patients with Hashimoto's thyroiditis and non-immunogenic hypothyroidism.
• The Systemic Inflammation Index (SII) emerged as the most potent marker for predicting inflammation in these thyroid conditions.